Question 1

What is fibrinogen deficiency?

Accepted Answer

Fibrinogen deficiency, also known as Factor I deficiency, is a rare blood clotting disorder where the body produces too little fibrinogen or none at all. Fibrinogen is essential for forming stable blood clots.

Question 2

What is acquired fibrinogen deficiency?

Accepted Answer

Acquired fibrinogen deficiency develops later in life, often due to conditions like liver disease, disseminated intravascular coagulation (DIC), major trauma, or certain medications that affect clotting.

Question 3

What causes fibrinogen deficiency?

Accepted Answer

It can be inherited through mutations in the FGA, FGB, or FGG genes, or acquired due to bleeding complications, liver dysfunction, or severe systemic illness.

Question 4

What are the symptoms of fibrinogen deficiency?

Accepted Answer

Symptoms include nosebleeds, heavy menstruation, delayed wound healing, or spontaneous internal bleeding in severe cases.
Source: MedlinePlus Genetics

Question 5

Is fibrinogen deficiency inherited or acquired?

Accepted Answer

It can be either inherited (congenital) or acquired due to external medical conditions such as liver disease or DIC.
Source: NORD (National Organization for Rare Disorders)

Question 6

How is fibrinogen deficiency diagnosed?

Accepted Answer

Diagnosis involves blood tests such as fibrinogen activity assays, Clauss method tests, and sometimes genetic testing to confirm inherited forms.

Question 7

How is fibrinogen deficiency managed?

Accepted Answer

Treatment may include fibrinogen concentrate infusions, cryoprecipitate, or fresh frozen plasma to restore clotting function during bleeding episodes or surgery.

Question 8

Does fibrinogen affect PT and aPTT levels?

Accepted Answer

Yes. Low fibrinogen levels can prolong both the prothrombin time (PT) and activated partial thromboplastin time (aPTT), indicating a clotting abnormality.

Question 9

What does Factor I do in the clotting process?

Accepted Answer

Fibrinogen (Factor I) is converted into fibrin, the protein that forms the mesh of a blood clot. Without it, clots are weak or fail to form properly.

Question 10

What are the risks of fibrinogen deficiency during surgery or childbirth?

Accepted Answer

People with fibrinogen deficiency face a higher risk of excessive bleeding during medical procedures, childbirth, or trauma. Preventive treatment is often needed in these situations.

Fibrinogen Deficiency Medications