Question 1

What is acromegaly characterized by?

Accepted Answer

Acromegaly is characterized by abnormal enlargement of bones and soft tissues, particularly in the hands, feet, and face. It usually develops slowly due to prolonged exposure to excess growth hormone.
Source: NIDDK – National Institute of Diabetes and Digestive and Kidney Diseases

Question 2

What is the difference between acromegaly and gigantism?

Accepted Answer

The key difference lies in timing. Acromegaly occurs in adults after growth plates have closed, while gigantism happens in children before bone growth stops, leading to excessive height.

Question 3

What are the symptoms of acromegaly?

Accepted Answer

Common symptoms include enlarged hands and feet, facial changes (such as a protruding jaw or brow), joint pain, thickened skin, and deepened voice. Symptoms often develop gradually.

Question 4

How is acromegaly diagnosed?

Accepted Answer

Acromegaly is typically diagnosed through blood tests that measure growth hormone and IGF-1 levels. A glucose tolerance test and MRI of the pituitary gland are also commonly used.

Question 5

Which hormone is involved in acromegaly?

Accepted Answer

Acromegaly is caused by excessive production of growth hormone (GH), usually due to a benign tumor in the pituitary gland.

Question 6

Who is most at risk for acromegaly?

Accepted Answer

Acromegaly usually affects adults between ages 30 and 50. It’s not inherited but develops spontaneously in most cases, often due to pituitary tumors.

Question 7

What complications can acromegaly cause?

Accepted Answer

Acromegaly can lead to serious complications such as high blood pressure, type 2 diabetes, sleep apnea, joint problems, and heart disease if left untreated.

Question 8

Can acromegaly be reversed?

Accepted Answer

While acromegaly itself isn’t typically reversible, treatment can control hormone levels, stop further growth changes, and reduce complications over time.

Question 9

What does acromegaly look like?

Accepted Answer

Visible signs may include a larger jaw or forehead, spaced teeth, enlarged hands or feet, and thicker skin. These features develop gradually and vary by person.

Question 10

Who treats acromegaly?

Accepted Answer

Acromegaly is usually treated by an endocrinologist. A care team may also include neurosurgeons, radiologists, and other specialists depending on the case.

Acromegaly Medications